Potential of Equine Herpesvirus 1 as a Vector for Immunization
نویسندگان
چکیده
منابع مشابه
Potential of equine herpesvirus 1 as a vector for immunization.
Key problems using viral vectors for vaccination and gene therapy are antivector immunity, low transduction efficiencies, acute toxicity, and limited capacity to package foreign genetic information. It could be demonstrated that animal and human cells were efficiently transduced with equine herpesvirus 1 (EHV-1) reconstituted from viral DNA maintained and manipulated in Escherichia coli. Betwee...
متن کاملEquine herpesvirus-1 consensus statement.
Equine herpesvirus-1 is a highly prevalent and frequently pathogenic infection of equids. The most serious clinical consequences of infection are abortion and equine herpesvirus myeloencephalopathy (EHM). In recent years, there has been an apparent increase in the incidence of EHM in North America, with serious consequences for horses and the horse industry. This consensus statement draws toget...
متن کاملEquine herpesvirus 1 utilizes a novel herpesvirus entry receptor.
The well-described herpesvirus entry receptors HveA (TNFRSF14), HveB (nectin 2), and HveC (nectin 1) have been shown to mediate the entry of alphaherpesviruses. Our findings showed that the alphaherpesvirus equine herpesvirus 1 (EHV-1) efficiently entered and replicated in CHO-K1 cells that lack the entry receptors HveA, HveB, and HveC, demonstrating that EHV-1 utilizes a unique entry receptor....
متن کاملA critical view on Equine Herpesvirus-1 and on Equine Herpesvirus-associated Myeloencephalopathy (EHM)
An infection with Equine herpesvirus type 1 (EHV-1), officially and by convention now called EQUID Herpesvirus, is the cause for Equine herpesvirus-associated Myeloencephalopathy or EHM. In 2008 the USDA declared this syndrome an ‘emerging disease’ among horse populations in the U.S.A., which indicates that EHM is perceived as an expanding problem that is observed more frequently when compared ...
متن کاملCharacterization of Glycoproteins in Equine Herpesvirus-1
In this study, we attempted to express twelve glycoproteins of equine herpesvirus-1 (EHV-1) in 293T cells and to characterize these using monoclonal antibodies (MAbs) and horse sera against EHV-1. Expression of glycoprotein B (gB), gC, gD, gG, gI and gp2 was recognized by immunoblot analysis using horse sera, but that of gE, gH, gK, gL, gM and gN was not. Four MAbs recognized gB, four recognize...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Virology
سال: 2005
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.79.9.5445-5454.2005